Table 3. Chronic oral treatment with minocycline prevents increases in plasma pro-inflammatory cytokines at 2 and 8 weeks post MI.
| naive (n = 4) |
Sham (n = 6) |
MI + Vehicle (n = 5) |
MI + Minocycline (n = 5) |
|
|---|---|---|---|---|
| 2 weeks (pg/ml) | ||||
| IL-1α | 94±8 | 131±20 | 129±18 | 100±17 |
| IL-1β | 97±10 | 225±27 | 298±66 ¶ | 147±26† |
| IL-2 | 172±12 | 199±38 | 206±26 | 202± 57 |
| IL-6 | 274±35 | 428±33 | 488±51 ¶ | 318± 43† |
| TNF-α | 275±13 | 281±22 | 255±14 | 272± 21 |
| IL-10 | 52 ±7 | 62±8 | 70±6 | 67± 13 |
| 8 weeks (pg/ml) | (n = 7) | (n = 7) | (n = 8) | |
| IL-1α | 87±7 | 99±4 | 92±7 | |
| IL-1β | 74±9 | 82±8 | 62±4 | |
| IL-2 | 167±10 | 176±4 | 158±9 | |
| IL-6) | 383±17 | 467±36 ** | 396±10 | |
| TNF-α | 357±23 | 410±6 * | 398±10* | |
| IL-10 | 158±15 | 178±5 | 159±7 |
Values are means ± SE
One-way ANOVA for plasma at 2 weeks, IL-1β: F = 4.7, p = 0.02, and for plasma IL-6: F = 4.8, p = 0.02.
One-way ANOVA for plasma at 8 weeks, IL-6: F = 4.0, p = 0.04, and for plasma TNF-α: F = 3.9, p = 0.04.
¶ p<0.05 vs. naïve,
*p<0.05 vs. Sham,
† p = 0.07 vs. MI+ Veh.
**p<0.05 vs. others