Table 1.

Brighton criteria for anaphylaxis¹⁴

Organ systems	Major criteria	Minor criteria
Dermatological or mucosal	Generalised urticaria (hives) or generalised erythema Angioedema (not hereditary), localised or generalised Generalised pruritus with skin rash	Generalised pruritus without skin rash Generalised prickle sensation Localised injection site urticarial Red and itchy eyes
Cardiovascular	Measured hypotension Clinical diagnosis of uncompensated shock indicated by at least three of the following: Tachycardia Capillary refill >3 s Reduced central pulse volume Decrease level or loss of consciousness	Reduced peripheral circulation as indicted by the combination of at least two of: Tachycardia A capillary refill time of >3 s without hypotension A decreased level of consciousness
Respiratory	Bilateral wheeze (bronchospasm) Stridor Upper airway swelling (lip, tongue, throat, uvula or larynx) Respiratory distress, defined by two or more of the following: Tachypnoea Increased use of respiratory muscles Recession Cyanosis Grunting	Persistent dry cough Hoarse voice Difficulty breathing without wheeze or stridor Sensation of throat closure Sneezing, rhinorrhoea
Gastrointestinal		Diarrhoea Abdominal pain Nausea Vomiting
Laboratory		Mast cell tryptase elevation >upper normal limit