Table 3: Determinants of serum NfL levels within the study population.
This table examines univariable and multivariable associations between risk factors for cardiovascular disease and serum NfL values. The unadjusted values are univariable associations with NfL. The adjusted values are multivariable associations after adjusting for variables with significant univariable associations (age, race, systolic blood pressure, glomerular filtration rate, high density lipoprotein, low density lipoprotein, years of diabetes and hemoglobin A1C).
| Unadjusted | Adjusted | |||
|---|---|---|---|---|
| β(SE) | p-Value | β(SE) | p-Value | |
| Age in years | 0.48 (0.09) | <0.01 | 0.36 (0.09) | <0.01 |
| Female | −0.95 (1.24) | 0.44 | ||
| Non-Caucasian race | 4.71 (1.38) | <0.01 | 3.57 (1.33) | <0.01 |
| Cardiovascular disease history | 1.66 (1.29) | 0.20 | ||
| Cigarette smoking history | 0.31 (1.85) | 0.87 | ||
| Left ventricular hypertrophy | 0.73 (1.16) | 0.53 | ||
| Antihypertensive medication use | −0.003 (1.61) | 0.99 | ||
| Systolic blood pressure | 0.16 (0.03) | <0.01 | 0.11 (0.03) | <0.01 |
| Diastolic blood pressure | −0.01 (0.06) | 0.81 | ||
| Glomerular filtration rate <60 ml/min/1.73m2 | 9.87 (1.97) | <0.01 | 8.01 (1.92) | <0.01 |
| Total cholesterol | 0.03 (0.01) | 0.07 | ||
| High density lipoprotein | 0.12 (0.05) | 0.01 | 0.03 (0.05) | 0.36 |
| Low density lipoprotein | 0.04 (0.02) | 0.04 | 0.02 (0.02) | 0.13 |
| Triglycerides | −0.004(0.004) | 0.37 | ||
| Years of diabetes | 0.25 (0.08) | <0.01 | 0.09 (0.08) | 0.27 |
| Hemoglobin A1C | 1.95 (0.67) | <0.01 | 1.85 (0.64) | <0.01 |