Table 1.
Baseline characteristics of 2,673 donors
| Clinical Characteristics | Mean ± SD or n (%) |
|---|---|
| Age at Biopsy, years | 43.7 ± 11.8 |
| Male | 1,095 (41.0%) |
| BMI, kg/m2 | 27.5 ± 4.7 |
| Systolic blood pressure, mmHg | 118.7 ± 14.4 |
| Diastolic blood pressure, mmHg | 73.4 ± 9.5 |
| eGFR, ml/min/1.73 m2 | 92.8 ± 16.2 |
| mGFR, ml/min/1.73 m2 | 104.1 ± 19.9 |
| Urine Albumin, mg† | 4.59 ± 11.44 |
| Urine Albumin ≥5mg† | 651 (33.5%) |
| Living related donor | 1350 (51.3%) |
| Hypertension | 426 (15.9%) |
| Nephron size and number measures* | |
| Glomerular Volume, mm3 | 0.0025 ± 0.0010 |
| Cortex volume per glomerulus, mm3 | 0.071 ± 0.036 |
| Tubular cross-sectional area, μm2 | 4,241 ± 1,438 |
| Nephron number per kidney | 942,000 ± 430,000 |
| CT nephrosclerosis measures | |
| Cortex volume / Medulla volume | 2.59 ± 0.66 |
| Diameter of largest cyst, cm‡ | 0.17 ± 0.60 |
| Biopsy nephrosclerosis measures* | |
| Number of IF/TA Foci | |
| 0 | 1953 (73%) |
| 1 | 439 (16%) |
| 2 | 120 (4.5%) |
| 3 | 84 (3.1%) |
| 4 | 45 (1.7%) |
| ≥5 | 32 (1.1%) |
| Percentage IF/TA Groups | |
| 0% | 2263 (85%) |
| 1–5% | 330 (12%) |
| 6–10% | 63 (2.4%) |
| >10% | 17 (0.6%) |
| Luminal Stenosis, % | 33.6 ± 21.2 |
| Globally sclerotic glomeruli, % | 3.2 ± 6.0 |
*
Biopsies used had a mean ± SD cortical area of 6.7 ± 3.0 mm2 and number of glomeruli of 19 ± 11 per section.
†
Not obtained in 731 donors.
‡
If no cysts were present, these patients were given a value of “0” cm for size.