Table 2.

Age-based thresholds used to define nephrosclerosis in 2673 donors (targeting as close to 5% abnormal as possible).

Nephrosclerosis measures	n	Age	Threshold	n(%) Abnormal
CT-based
Cortex / Medulla volume
	344	18–29	<1.97	18 (5.2%)
	616	30–39	<1.81	30 (4.9%)
	706	40–49	<1.73	34 (4.8%)
	545	50–59	<1.60	27 (5.0%)
	222	60+	<1.53	11 (5.0%)
Largest kidney cyst diameter, cm
	372	18–29	≥0.1	17 (4.6%)
	665	30–39	≥0.5	41 (6.2%)
	770	40–49	≥1.0	45 (5.8%)
	584	50–59	≥1.3	34 (5.8%)
	242	60+	≥2.6	14 (5.8%)
Biopsy-based
Globally sclerotic glomeruli
	376	18–29	*	16 (4.3%)
	676	30–39	*	55 (8.1%)
	784	40–49	*	52 (6.6%)
	592	50–59	*	26 (4.4%)
	245	60+	*	18 (7.4%)
% IF/TA
	376	18–29	≥1%	25 (6.7%)
	676	30–39	≥1%	61 (9.0%)
	784	40–49	≥1%	112 (14.3%)
	592	50–59	≥5%	20 (3.4%)
	245	60+	≥10%	13 (5.3%)
Number of IF/TA foci
	376	18–29	≥2	9 (2.4%)
	676	30–39	≥2	36 (5.3%)
	784	40–49	≥3	39 (5.0%)
	592	50–59	≥3	47 (7.9%)
	245	60+	≥5	19 (7.7%)
% Luminal stenosis
	332	18–29	≥59.5%	17 (5.1%)
	604	30–39	≥62.8%	31 (5.1%)
	690	40–49	≥68.9%	34 (4.9%)
	533	50–59	≥74.0%	27 (5.1%)
	225	60+	≥76.9%	11 (4.9%)
CT- and Biopsy-based
Nephron number†
	344	18–29	<393,000	17 (4.9%)
	616	30–39	<443,000	31 (5.0%)
	705	40–49	<382,000	35 (5.0%)
	543	50–59	<348,000	28 (5.2%)
	222	60+	<314,000	12 (5.4%)

^*Previously published thresholds using a subset depend on both age and number of glomeruli per section (See table S1).(7)

^†These thresholds are low and not monotonic, in part, due to measurement error with nephron number (test-retest CV of 33%). (5)