Table 3.
Predictors of mGFR measures at follow-up among 1,057 donors
| Residual mGFR (mGFRfollow-up/mGFRpre-donation ×100%) | Follow-up mGFR <60 (y/n) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline clinical characteristics | Unadjusted | Adjusted for age and follow-up time | Further adjusted for all clinical characteristics | Unadjusted | Adjusted for age and follow-up time | Further adjusted for all clinical characteristics | ||||||
| Est | P | Est | P | Est | P | OR | P | OR | P | OR | P | |
| Age, per year | −0.2% | <0.001 | - | - | - | - | 1.11 | <0.001 | - | - | - | - |
| Male | 1.4% | 0.06 | 0.9% | 0.21 | - | - | 0.93 | 0.56 | 1.18 | 0.28 | - | - |
| BMI, per kg/m2 | −0.1% | 0.10 | −0.1% | 0.12 | - | - | 1.04 | 0.009 | 1.04 | 0.01 | - | - |
| Systolic blood pressure, per 10 mmHg | −0.3% | 0.26 | −0.3% | 0.34 | - | - | 1.15 | 0.002 | 1.01 | 0.81 | - | - |
| Diastolic blood pressure, per 10 mmHg | −0.5% | 0.17 | −0.2% | 0.58 | - | - | 1.26 | 0.001 | 1.07 | 0.42 | - | - |
| mGFR, per 10 ml/min/1.73 m2* | −2.2% | <0.001 | −3.2% | <0.001 | - | - | 0.48 | <0.001 | 0.56 | <0.001 | - | - |
| Urine Albumin ≥5mg | 1.2% | 0.13 | −0.1% | 0.92 | - | - | 0.94 | 0.67 | 1.31 | 0.11 | - | - |
| Living related donor | 1.4% | 0.06 | 0.0% | 0.95 | - | - | 0.60 | <0.001 | 1.02 | 0.92 | - | - |
| Hypertension | −3.0% | 0.001 | −1.4% | 0.14 | - | - | 2.56 | <0.001 | 1.20 | 0.33 | - | - |
| Nephron Size | ||||||||||||
| Glomerular volume, per SD | 0.3% | 0.47 | 0.0% | 0.91 | 0.1% | 0.82 | 1.05 | 0.46 | 1.18 | 0.02 | 1.19 | 0.04 |
| Cortex volume per glomerulus, per SD | 0.2% | 0.57 | 0.2% | 0.67 | 0.1% | 0.83 | 1.13 | 0.04 | 1.09 | 0.20 | 1.02 | 0.80 |
| Tubular cross-sectional area, per SD | −0.1% | 0.71 | −0.3% | 0.36 | −0.2% | 0.63 | 1.05 | 0.44 | 1.05 | 0.47 | 1.09 | 0.32 |
| Nephron number | ||||||||||||
| Nephron number, <5% threshold | −0.3% | 0.87 | −0.7% | 0.67 | −1.9% | 0.19 | 1.53 | 0.11 | 1.72 | 0.08 | 1.32 | 0.42 |
| CT-based nephrosclerosis | ||||||||||||
| Cortex / Medulla volume, <5% threshold | 2.1% | 0.22 | 1.6% | 0.33 | 1.3% | 0.39 | 1.10 | 0.75 | 1.10 | 0.79 | 0.96 | 0.90 |
| Largest cyst diameter, >95% threshold | −2.4% | 0.12 | −2.1% | 0.17 | −0.5% | 0.72 | 1.28 | 0.36 | 1.16 | 0.63 | 1.38 | 0.36 |
| Biopsy-based nephrosclerosis | ||||||||||||
| Globally sclerotic glomeruli >95% threshold | −1.8% | 0.22 | −1.7% | 0.24 | −1.6% | 0.22 | 0.91 | 0.72 | 0.84 | 0.56 | 0.75 | 0.40 |
| % IF/TA, >95% threshold | −0.1% | 0.93 | −0.4% | 0.78 | −0.9% | 0.49 | 1.42 | 0.14 | 1.61 | 0.07 | 1.67 | 0.08 |
| Number of IF/TA foci, >95% threshold | −1.4 | 0.35 | −0.2% | 0.89 | −0.7% | 0.59 | 2.80 | <0.001 | 1.97 | 0.02 | 1.99 | 0.04 |
| Artery luminal stenosis, >95% threshold | 1.6% | 0.43 | 0.9% | 0.63 | 1.4% | 0.42 | 0.40 | 0.03 | 0.45 | 0.08 | 0.38 | 0.05 |
*
Association reflects regression to the mean.