Table 4.
Urine albumin ≥5 mg at follow-up, among donors with baseline urine albumin <5 mg (n=712)
| Follow-up urine albumin ≥5mg | ||||||
|---|---|---|---|---|---|---|
| Baseline clinical characteristics | Unadjusted | Adjusted for age and follow-up time | Further adjusted for all clinical characteristics | |||
| OR | P | OR | P | OR | P | |
| Age, per year | 0.99 | 0.53 | - | - | - | - |
| Male | 1.02 | 0.95 | 1.01 | 0.95 | - | - |
| BMI, per kg/m2 | 1.05 | 0.05 | 1.05 | 0.04 | - | - |
| Systolic blood pressure, per 10 mmHg | 1.31 | <0.001 | 1.28 | 0.005 | - | - |
| Diastolic blood pressure, per 10 mmHg | 0.96 | 0.75 | 0.94 | 0.61 | - | - |
| eGFR, per 10 ml/min/1.73 m2 | 1.16 | 0.03 | 1.25 | 0.01 | - | - |
| Living related donor | 1.08 | 0.74 | 1.02 | 0.94 | - | - |
| Hypertension | 0.92 | 0.79 | 0.96 | 0.90 | - | - |
| Nephron Size | ||||||
| Glomerular volume, per SD | 1.29 | 0.02 | 1.29 | 0.03 | 1.25 | 0.07 |
| Cortex volume per glomerulus, per SD | 1.38 | 0.002 | 1.36 | 0.003 | 1.39 | 0.003 |
| Tubular cross-sectional area, per SD | 1.26 | 0.04 | 1.21 | 0.11 | 1.18 | 0.17 |
| Nephron number | ||||||
| Nephron number, <5% threshold | 3.41 | 0.002 | 3.22 | 0.004 | 4.67 | <0.001 |
| CT-based nephrosclerosis | ||||||
| Cortex / Medulla volume, <5% threshold | 0.97 | 0.96 | 0.88 | 0.81 | 1.02 | 0.97 |
| Largest cyst diameter, >95% threshold | 0.93 | 0.89 | 0.94 | 0.90 | 1.02 | 0.97 |
| Biopsy-based nephrosclerosis | ||||||
| Globally sclerotic glomeruli >95% threshold | 0.89 | 0.80 | 0.81 | 0.65 | 0.74 | 0.53 |
| % IF/TA, >95% threshold | 1.98 | 0.07 | 1.60 | 0.23 | 1.40 | 0.41 |
| Number of IF/TA foci, >95% threshold | 0.48 | 0.22 | 0.50 | 0.26 | 0.48 | 0.24 |
| Artery luminal stenosis, >95% threshold | 1.43 | 0.58 | 1.46 | 0.57 | 1.20 | 0.79 |