Figure 5.
rh-IFN-α administration improved long-term motor and memory function at 21-28 days after GMH. rh-IFN-α improved GMH pups’ motor function evaluated by rotarod test (A, B) and foot fault (C). rh-IFN-α treatment significantly improved memory function as shown by less swim distance (E), escape latency (F) and more time in the target quadrant (G, H) in Morris water maze test, but the swim velocity (D) showed no significantly difference among three groups. * P<0.001 vs Sham, # P<0.001 vs Vehicle, one-way ANOVA, Tukey’s test, n=12.