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. Author manuscript; available in PMC: 2020 Aug 15.
Published in final edited form as: Neuroimage. 2019 Apr 30;197:243–254. doi: 10.1016/j.neuroimage.2019.04.070

Figure 7. An example of a false discovery of diffusion tensor imaging (DTI) sourced from the PVS bias.

Figure 7.

Mean diffusivity (MD) of the left superior fronto-occipital fasciculus of the cognitively normal (CN) group (n=37) and patients with mild cognitive impairment (MCI) diagnosis (n=24) are plotted in left. Comparison are made using both DTI and tissue tensor imaging (TTI) techniques. From DTI eyes, higher MD was significantly associated with the cognitive stage (p<0.001). However, when TTI was used, no difference was observed. PVS signal fraction of this region is plotted in right. The PVS signal fraction had significant association with the cognitive stage on this region (p<0.001). Age, sex and brain volume were included in the regression analysis as covariates. Diffusivity values are in μm2/ms.