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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Pharm Sci. 2019 Feb 18;108(7):2465–2475. doi: 10.1016/j.xphs.2019.01.034

Figure 3.

Figure 3.

Schematic of the single cell level PK-PD model for T-vc-MMAE ADC. The model incorporates growing (N1) and non-growing (N2–N4) populations of cells. The cellular disposition of T-vc-MMAE was assumed to be active in all populations of cells, where intracellular occupancy of tubulin with released unconjugated MMAE shuttles the cells from growing to non-growing phases using transit compartments leading to cell death. Upon the death of each cell, the intracellular content was assumed to release in the media and could freely exchange with other cells.