. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: J Pharm Sci. 2019 Feb 18;108(7):2465–2475. doi: 10.1016/j.xphs.2019.01.034

Table 1:

The list of state variables used in the differential equations for the model, and their definitions.

Variable Name	Definition
$N_{j}^{i}$	The number of tumor cells for each cell-type in a cell-distribution phase
ADC^M	Concentration (nM) of T-vc-MMAE in the media space
MMAE^M	Amount (nMoles) of unconjugated MMAE in the media space
$A D C_{b}^{i}$	Number of molecules of HER2-bound T-vc-MMAE on surface of a single cell
$A D C_{l y s o}^{i}$	Number of molecules of T-vc-MMAE internalized in endosomal/lysosomal space of a single cell
$M M A E_{f}^{i}$	Number of molecules of ‘free’ unconjugated MMAE in the intracellular space of a single cell
$M M A E_{b}^{i}$	Number of molecules of ‘tubulin bound’ unconjugated MMAE in the intracellular space of a single cell
$\bar{D A R}$	Average Drug: Antibody Ratio of T-vc-MMAE at a given time