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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Xenotransplantation. 2019 Feb 15;26(3):e12497. doi: 10.1111/xen.12497

Table 1:

Major in vivo experiments of pig liver transplantation in NHPs

Year Donor pig Recipient Immunosuppressive regimen Max. survival. (days) Type of Tx First author Ref.
1968 WT Baboon Aza, Cs <1–3 Orthotopic Calne 85
1970 WT Rhesus ALG <1 Orthotopic Calne 87
1970 WT Chimpanzee ALG <1 Orthotopic Calne 86
1994 WT Cynomolgus Gal-depletion, WBI, ATG, pig BMTx, <1–3 Orthotopic Powelson 88
1998 WT Rhesus CsA, CTX, Cs <1 Orthotopic Luo 89
1998 WT Baboon sCR1 <1 Auxiliary orthotopic Hayashi 12
2000 hCD55 Baboon CsA, CyP, Cs 8 Orthotopic Ramirez 66
2005 hCD55.hCD59.HT Baboon CyP, Dacluzimab, Cs, Rituximab, CsA, MMF. 1 Orthotopic Ramirez 67
2010 GTKO Baboon ATG, Tac, MMF, Cs <1 Orthotopic Ekser 84
2010 GTKO.hCD46 Baboon CyP, Tac, MMF, Cs 7 Orthotopic Ekser 65
2012 GTKO Baboon ATG, CVF, Tac, Aza, Cs, aCD154mAb, LoCD2b 9 Orthotopic Kim 20
2014 GTKO Baboon ATG, CVF, Tac, Cs 15 Auxiliary heterotopic Yeh 13
2014 GTKO Tibetan macaque ATG, CVF, Cs, Tac, MMF, aCD154mAb 14 Auxiliary heterotopic Ji 14
2015 GTKO Baboon ATG, CVF, Tac, Cs 7 Orthotopic Navarro-Alvarez 30
2016 GTKO Baboon ATG, CVF, Belatacept, Tac, Cs 25 Orthotopic Shah 21
2017 GTKO Baboon ATG, CVF, Tac, Cs, aCD40mAb 29 Orthotopic Shah 11

Abbreviations: ALG/ATG=anti-thymocyte globulin; Aza=azathioprine; BMTx=bone marrow transplantation; CS=corticosteroids; CsA=cyclosporine; CTX=cytoxan; CyP=cyclophosphamide; CVF=cobra-venom factor; Gal=galactose-α1,3-galactose; GTKO=α-1,3-galactosyltransferase knock out; mAb=monoclonal antibody; MMF=mycophenolate mofetil; sCR1=soluble complement-receptor-1; Tac=tacrolimus; WBI=whole body irradiation.