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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Mol Genet Metab. 2018 Dec 24;128(3):204–212. doi: 10.1016/j.ymgme.2018.12.007

Fig.2. The ins and outs of heme transport.

Fig.2

Mitochondrial isoform FLVCR1b transports heme into the cytosol. ABCB10 is reported to forms complex with FECH and MFRN1. It is not clear whether ABCB10 transport heme. The cell surface FLVCR1a and the ABC transporter ABCG2 have been implicated in heme e xport. MPR5 is a heme exporter which can transport heme from cytosol to the secretory pathway. HCP1 is a folate importer as well as a low-affinity heme importer. HRG-1 is a heme importer that localizes to endosomal/lysosomal compartments, but also traffics to the plasma membrane.