. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Mol Genet Metab. 2018 Dec 24;128(3):204–212. doi: 10.1016/j.ymgme.2018.12.007

Table 1.

Summary of zebrafish mutants related to heme -iron metabolism

Genes	Mutant Name or Morpholino Knockdown	Potential Human Disease	References
*ALAS2*	sauternes (sau)	Congenital Sideroblastic Anemia (CSA)	[74]
*ALAD*	Alad^−/−	ALA dehydratase deficient porphyria (ADP)	[76]
*CPOX*	Cpox^−/−	Hereditary coproporphyria (HCP)	[76]
*UROD*	yquem (yqe)	Porphyria cutanea tarda (PCT) / hepato-erythropoietic porphyria (HEP)	[77]
*PPOX*	montalcino (mno)	Human variegate porphyria	[78]
*FECH*	Freixenet (frx) / dracula (drc)	Erythropoietic protoporphyria	[4] [78]
*GRX5*	shiraz (sir)	Sideroblastic anemia	[80] [81]
*MFRN1*	frascati (frs)	Erythropoietic protoporphyria	[27]
*DMT-1*	chardonnay (cdy)	Hypochromic microcytic anemia	[85] [86]
*FPN1*	weissherbst (wei)	Iron-deficient anemia	[87] [88]
TF	gavi	congenital hypotransferrinemia	[90]
*TFR1*	chianti (cia)	hypochromic anemia	[92]
*HRG1*	hrg1a;hrg1b (CRISPR)	unknown	[73]
FLVCR	Morpholino Knockdown	Heme toxicity	[96]