Mutations of patients with Hz/Hc alter the electrostatic potential of PSTPIP1. A, PSTPIP1 FCH domain in a ribbon diagram of PSTPIP1 dimer with Hz/Hc mutations (green). B, p.E250 in a cluster of 4 negatively charged side chains. C-G, Electrostatic potential in (blue, positive charge; red, negative charge; Fig 2, C) in WT (Fig 2, D), p.E250K (Fig 2, E), p.E257K (Fig 2, F), and p.E250Q mutants (Fig 2, G).