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. 2019 Mar 13;197(1):83–94. doi: 10.1111/cei.13282

Figure 1.

Figure 1

Tonsil cell proliferation in response to purified streptococcal superantigens or streptococcal supernatants. Tonsil cells were stimulated for 7 days with different concentrations of purified superantigens streptococcal pyrogenic exotoxin (SpeA) or streptococcal mitogenic exotoxin Z (SmeZ) (a) or 1% supernatants from isogenic emm1 or emm89 strains (b). emm1 supernatants were from parent [wild‐type (WT)]; isogenic speA negative (WTΔspeA); and complemented (WTΔspeAcomp) strains. emm89 supernatants were from parent (WT); isogenic smeZ‐negative (WTΔsmeZ); complemented (WTΔsmeZcomp); and SpeA‐complemented (WTspeAcomp) strains. Unstimulated control cells (neg) were incubated with medium alone. Data show one donor with mean and experimental triplicates; representative of six different tonsil donors for supernatants (P = 0·0047, Friedman test).