Table 2.
Antimicrobial activities of amurin-9KY and its derivatives
| MIC (g/mL) | ||||
|---|---|---|---|---|
| Microorganism | Amurin- | Amurin- | Amurin- | Amurin- |
| 9KY | 9KY1 | 9KY2 | 9KY3 | |
| Gram-positive | ||||
| Staphylococcus aureus ATCC25923 | 4.68 | 37.5 | ND | ND |
| Staphylococcus aureus 090223+ (IS) | 37.5 | 75 | ND | ND |
| Nocardia asteroids 090312+ (IS) | 37.5 | 75 | ND | ND |
| Gram-negative | ||||
| Escherichia coli ATCC25922 | ND | ND | ND | ND |
| Klebsiella pneumonia 1368 (IS) | ND | ND | ND | ND |
| Pseudomonas aeruginosa ATCC27853 | ND | ND | ND | ND |
| Fungi | ||||
| Candida albicans ATCC2002 | ND | ND | ND | ND |
| Slime mold 090413 (IS) | ND | 75 | ND | ND |
MIC: Minimum inhibitory concentration. These concentrations represent mean values of three independent experiments performed in duplicate. IS: Clinically isolated strain. ND: No detectable activity in inhibition zone assay at a dose of 2 mg/mL.