Table 1.

Compound potencies in the human IL-36γ evoked CXCL1 release assays from cells.

Compound	Human HaCaT cells, Ki	Mouse NIH-3T3 cells, Ki
A-706	121 ± 32 nM	181 ± 54 nM
A-552	31 ± 22 nM	54 ± 10 nM
A-553	3.7 ± 2.3 μM	3.7 ± 1.7 μM

Ki average 3 independent experiments (n = 4 Human HaCaT A-552 and A-553, n = 2 for Mouse NIH 3T3 A-553) is shown ± S.D.