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. 2019 Jun 24;5:107. doi: 10.1038/s41420-019-0187-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PA homeostasis maintained by PfPAP2 is essential for parasite growth. Blocking the PAP activity of PfPAP2 creates PA imbalance in P. falciparum. This breakdown in PA homeostasis promotes preterm egress of merozoites, which then fail to survive in the host environment leading to limited growth of parasite. PfPAP2 clearly stands out as an important regulator, maintaining the PA homeostasis that is crucial for parasite to flourish