Fig. 2. Expression of TRPV4 in human tumor samples obtained from oncomine.

Data obtained from oncomine and the table are made by the data set from PAAD (pancreatic adenocarcinoma): series GSE16515 (title: FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt), with p-value of 8.93E-4, and 52 patients samples were used for this analysis; COAD (colon adenocarcinoma): series GSE5206 (title: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer), with p-value of 5.56E-7, and 46 patients samples were used for this analysis; LIHC (liver hepatocellular carcinoma): series GSE14323 (title: Genes involved in viral carcinogenesis and tumor initiation in Hepatitis C virus-induced hepatocellular carcinoma), with p-value of 1.36E-9, and 57 patients samples were used for this analysis; LUAD (lung adenocarcinoma): series GSE19188 (title: Gene expression-based classification of non-small cell lung carcinomas and survival prediction), with p-value of 0.002, and 110 patients samples were used for this analysis; LUSC (lung squamous cell carcinoma): series GSE19188 (title: Gene expression-based classification of non-small cell lung carcinomas and survival prediction), with p-value of 5.18E-9, and 92 patients samples were used for this analysis; BLCA (bladder urothelial carcinoma): series GSE13507 (title: Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors), with p-value of 0.035, and 130 patients samples were used for this analysis; BRCA (breast invasive carcinoma): series GSE9014 (Title: Stromal gene expression predicts clinical outcome in breast cancer), with p-value of 3.54E-7, and 59 patients samples were used for this analysis; HNSC (head-and-neck squamous cell carcinoma): series GSE7410 (title: Gene expression in early stage cervical cancer), with p-value of 0.908, and 54 patients samples were used for this analysis; UCEC (uterine corpus endometrial carcinoma): series GSE19188 (title: Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas), with p-value of 0.067, and 45 patients samples were used for this analysis; PRAD (prostate adenocarcinoma): series GSE21034 (title: Whole-transcript and exon-level expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate), with p-value of 3.71E-12, and 160 patients samples were used for this analysis; STES (esophageal carcinoma): series GSE13898 (title: Robust prognostic biomarkers for EAC identified by systems-level characterization of tumor transcriptome), with p-value of 6.58E-9, and 40 patients samples were used for this analysis. We queried oncomine for each of those specific cancers to compare the fold change of TRPV4 in cancer tissue cells with normal tissue cells. All p-values represent a Student’s t test