Fig. 5.
A weak-gel model reproduces VH-DHJH first-encounter times. a Tuning the lifetime of crosslinks results in a systematic change in the slope (α) of the MSD. Short-lived bonds (lifetime ~10 s) yield the best agreement between MSD derived from experiment and simulations. b Representative trajectories of the spatial distance within individual VH-DHJH pairs in STI-571 treated cells (n = 121). Red circles indicate potential first encounters. c Representative trajectories of VH-DHJH spatial distances generated from the MD simulations of the Igh locus when modeled as a weak gel. d First encounter times as a function of mean spatial separation from experimental and simulated VH-DHJH trajectories (left panel), and the corresponding probability distributions of experimentally derived and simulated first-encounter times (right panel). Source data is provided as a Source Data File