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. 2019 Jun 24;9:9130. doi: 10.1038/s41598-019-45589-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PIK3CA-HER3 dual targeting has synergistic effects in HNSCC. (A) Combination BYL719 (1 µM, 24 hours) and KTN3379 (100 nM, 1 hour) inhibits signaling along HER3-PIK3CA-AKT axis more effectively than single agent treatment with either compound in FaDu, PE/CA-PJ34, and Cal33 HNSCC cells. (B) BYL719 and KTN3379 demonstrate synergistic growth inhibition in colony formation assay. Significance assessed by one way ANOVA comparing BYL719 vs. Combined and KTN3379 vs. Combined presented in lower panel. (C) BYL719 and KTN3379 demonstrate synergy (Combination Index <1) in multiple HNSCC cell lines in growth assay. Drug added in fixed ratio (100:1). Data presented as mean ± SEM unless as otherwise indicated; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Blots cropped for conciseness; full length images available in Supplementary Data.