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. 2019 Jun 18;9:514. doi: 10.3389/fonc.2019.00514

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Copyright © 2019 Ji, Yang, Cai, Wang, Lei, Wu, Cui, Yang, Chen and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The reversal effect of midostaurin on ABCB1-mediated MDR in ABCB1-gene-transfected cells. IC₅₀ values of (A) doxorubicin, (B) paclitaxel, (C) colchicine, and (D) cisplatin in parental HEK293/pcDNA3.1 and transfected ABCB1-overexpression HEK293/ABCB1 cells with or without treatment of midostaurin. Data are expressed as mean ± SD, representative of at least three independent experiments. ^*P < 0.05, compared with control group.