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. 2019 Jun 18;9:514. doi: 10.3389/fonc.2019.00514

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Copyright © 2019 Ji, Yang, Cai, Wang, Lei, Wu, Cui, Yang, Chen and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The reversal effect of midostaurin on ABCG2-mediated MDR in ABCG2-overexpression cancer cells. (A) IC₅₀ values of mitoxantrone in parental NCI-H460 cells and resistant NCI-H460/MX20 cells. (B) IC₅₀ values of cisplatin in parental NCI-H460 cells and resistant NCI-H460/MX20 cells. ^*P < 0.05, compared with control group.