Table 1.
Overview of dental disease phenotypes in GLIDE
| Trait name | DMFS | DFSS | Nteeth | Periodontitis |
|---|---|---|---|---|
| Trait | Decayed, missing and filled tooth surfaces | Decayed and filled tooth surfaces standardised to number of tooth surfaces | Number of natural teeth | Presence or absence of periodontitis |
| Transformation | Standard deviation of tooth surface residuals | Inverse normal rank transformation | — | |
| Phenotypic assessment | Derived from clinical dental records | Derived from clinical dental records or self-reported (WHGS) |
Centers for Disease Control and Prevention/American Academy of Periodontology definitions54 (four studies) Two or more tooth surfaces with probing depth ≥5 mm, or at least four tooth surfaces with probing depth ≥4 mm (1 study) Probing depth ≥5.5 mm in 2 or more sextants (1 study). Participant-reported diagnosis of periodontitis (1 study) |
|
| Number of studies in primary analysis | 9 | 8 | 9 | 7 |
| Number of participants in primary analysis | 26,792 | 26,533 | 27,949 | 17,353 cases, 28,210 controls |