Table 2.
Ten lead novel independent loci in DMFS/dentures combined analysis
| Locus* | rsid | Chr:Pos (b37) | EA:EAF | DMFS/dentures | DMFS | Dentures | N | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta (se)† | P | Beta (se) | P | Beta (se) | P | |||||
| KRTCAP2 | rs4971099 | 1:155155608 | a:0.55 | −0.021 (0.0027) | 7.47E-15 | −0.024 (0.0089) | 0.006 | −0.040 (0.0055) | 3.24E-13 | 487821 |
| WNT10A | rs121908120 | 2:219755011 | a:0.03 | −0.081 (0.0083) | 2.03E-22 | −0.12 (0.039) | 0.0026 | −0.16 (0.017) | 1.94E-20 | 486339 |
| C5orf66 | rs1122171 | 5:134509987 | t:0.59 | 0.044 (0.0027) | 2.84E-62 | 0.064 (0.0087) | 2.40E-13 | 0.085 (0.0056) | 8.96E-52 | 487823 |
| FGF10 | rs1482698 | 5:44539453 | c:0.38 | 0.020 (0.0027) | 1.47E-13 | 0.023 (0.0092) | 0.014 | 0.040 (0.0057) | 3.10E-12 | 487823 |
| HLA | rs9366651 | 6:26336696 | t:0.51 | −0.029 (0.0026) | 2.66E-28 | −0.028 (0.0088) | 0.0014 | −0.058 (0.0055) | 4.47E-26 | 487822 |
| PBX3 | rs10987008 | 9:128661600 | a:0.64 | 0.021 (0.0028) | 7.47E-14 | 0.015 (0.009) | 0.093 | 0.042 (0.0058) | 2.52E-13 | 487822 |
| CA12 | rs72748935 | 15:63639416 | t:0.46 | −0.028 (0.0027) | 1.31E-26 | -0.052 (0.0092) | 1.60E-08 | −0.052 (0.0055) | 5.49E-21 | 487820 |
| FOXL1 | rs10048146 | 16:86710660 | a:0.81 | −0.026 (0.0034) | 5.20E-14 | −0.0236 (0.012) | 0.045 | −0.051 (0.007) | 3.85E-13 | 487820 |
| MC4R | rs28822480 | 18:57924823 | a:0.29 | 0.021 (0.0029) | 7.08E-13 | 0.044 (0.010) | 1.40E-05 | 0.037 (0.006) | 8.38E-10 | 487821 |
| MAMSTR | rs11672900 | 19:49220323 | a:0.47 | −0.020 (0.0027) | 4.67E-14 | −0.0092 (0.009) | 0.31 | −0.042 (0.0055) | 3.11E-14 | 487822 |
*The locus name refers to the protein-coding gene in the RefSeq database which is closest to the lead signal. †Estimates are from standardised regression coefficients