Figure 1.

Absence of Tau does not alter NMDA receptor levels in the hippocampus. Western blot (WB) analysis of the levels of Tau and of GluN2B subunits of NMDA receptors with an antibody directed against its N-terminus (A) or its C-terminus (B), and of GluN2A subunits of NMDA receptors (C), from hippocampal extracts of WT and Tau^−/− mice. Quantifications of GluN2B N-ter, GluN2B C-ter and GluN2A levels are shown on the right. Tau protein is not detected in Tau^−/− mice, and the levels of GluN2B N-ter, GluN2B C-ter and GluN2A subunits are not affected by the absence of Tau. Graphs show mean ± SEM. N = 7 mice per genotype. GAPDH was used as loading control. Blots were cropped to improve the clarity of the presentation. Full-length blots are presented in Supplementary Fig. 5.