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. 2019 Jun 18;10:635. doi: 10.3389/fneur.2019.00635

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Copyright © 2019 Martin, Wong and Hanaford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early-life brain trauma in APP-PS1 mice does not alter the cortical accumulation of Aβ. (A) Sagittal section stained immunohistochemically for Aβ. Cortical layers identified by numbers (left). White arrows identify parenchymal deposits of Aβ. Bar = 103 μm. (B) Graph showing the mean number of Aβ deposits in frontal-patietal-occipital cortex in APP-PS1 Tg mice with and without CCI. Values are mean ± SD (n = 6 mice/group).