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. 2019 Jun 24;10:2761. doi: 10.1038/s41467-019-10707-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cavernomas are composed of clones of Ccm3^−/− cells that attract Ccm3^+/+ cells. Representative images of retina (a, b) and cerebellum (c) from chronic Cdh5(PAC)-Cre-ER^T2/Ccm3^f/f/R26R-Confetti mice at P30. The vessels are counterstained with Isolectin B4 (a, b) or Podocalyxin (c) and are displayed as greyscale. d Three-dimensional reconstruction of mulberry cavernomas from P14 brain. The vessels are counterstained with Podocalyxin; L stands for Lumen. Scale bars, 500 μm (a); 100 μm (b); 50 μm (c), 100 μm (d). e–g Analysis of clones in normal vessels of Cdh5(PAC)-Cre-ER^T2/R26R-Confetti mice and normal vessels and lesions of Cdh5(PAC)-Cre-ER^T2/Ccm3^f/f/R26R-Confetti mice. e Distribution of the four fluorophores among clones. Data are means ± SE; n = 3 mice in each group. f Quantification of the number of cells that compose each clone. Data are means ± SE; n = 3 mice in each group. g Distribution of clone size. Clones were divided according to the number of cells they are composed of; each dot represents an animal. A total of 2371 clones were analysed from 3 mice in each group. Source data are provided as a Source Data file