Table 3.
List of 66 most plausible candidate genes for BW according to the following criteria: modular genes participating in enriched developmental processes, growth related modular genes not significantly enriched to any developmental process and growth related modular genes reported in previous studies.
| Criterion | Gene | Description | Module_ID | GGA |
|---|---|---|---|---|
| modular genes participating in enriched developmental processes | BTG2 | BTG anti-proliferation factor 2 | module_2 | 26 |
| ZAR1 | zygote arrest 1 | module_2 | 4 | |
| MEOX1 | mesenchyme homeobox 1 | module_2 | 27 | |
| KRT14 | keratin 14 | module_2 | 27 | |
| KRT15 | keratin 15 | module_2 | 27 | |
| TXK | TXK tyrosine kinase | module_2 | 4 | |
| CSF3 | colony stimulating factor 3 | module_2 | 27 | |
| ACAN | aggrecan | module_2 | 10 | |
| HOXB1 | homeobox B1 | module_2 | 27 | |
| HOXB2 | homeobox B2 | module_2 | 27 | |
| HOXB3 | homeobox B3 | module_2 | 27 | |
| HOXB4 | homeobox B4 | module_2 | 27 | |
| HOXB5 | homeobox B5 | module_2 | 27 | |
| HOXB6 | homeobox B6 | module_2 | 27 | |
| HOXB7 | homeobox B7 | module_2 | 27 | |
| HOXB8 | homeobox B8 | module_2 | 27 | |
| HOXB9 | homeobox B9 | module_2 | 27 | |
| HOXB13 | homeobox B13 | module_2 | 27 | |
| MDFI | MyoD family inhibitor | module_2 | 26 | |
| NES | nestin | module_2 | 25 | |
| TBX21 | T-box 21 | module_2 | 27 | |
| IGFBP4 | insulin like growth factor binding protein 4 | module_2 | 27 | |
| PRELP | proline and arginine rich end leucine rich repeat protein | module_2 | 26 | |
| HAPLN2 | hyaluronan and proteoglycan link protein 2 | module_2 | 25 | |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | module_2 | 10 | |
| GABRA4 | gamma-aminobutyric acid type A receptor alpha4 subunit | module_2 | 4 | |
| BCAN | brevican | module_2 | 25 | |
| NHLH1 | nescient helix-loop-helix 1 | module_2 | 25 | |
| ZBTB7B | zinc finger and BTB domain containing 7B | module_2 | 25 | |
| FZD10 | frizzled class receptor 10 | module_2 | 15 | |
| TCP11 | t-complex 11 | module_2 | 26 | |
| PIWIL1 | piwi like RNA-mediated gene silencing 1 | module_2 | 15 | |
| SPDEF | SAM pointed domain containing ETS transcription factor | module_2 | 26 | |
| ZFPM1 | zinc finger protein, FOG family member 1 | module_2 | 11 | |
| CBFA2T3 | CBFA2/RUNX1 translocation partner 3 | module_2 | 11 | |
| KRT17 | keratin 17 | module_2 | 27 | |
| CRABP2 | cellular retinoic acid binding protein 2 | module_2 | 25 | |
| SH2D2A | SH2 domain containing 2 A | module_2 | 25 | |
| NR1D1 | nuclear receptor subfamily 1 group D member 1 | module_2 | 27 | |
| STX2 | syntaxin 2 | module_2 | 15 | |
| TEC | tec protein tyrosine kinase | module_2 | 4 | |
| ETV3 | ETS variant 3 | module_2 | 25 | |
| PPARD | peroxisome proliferator activated receptor delta | module_4 | 26 | |
| ELF2 | E74 like ETS transcription factor 2 | module_4 | 4 | |
| ETV3L | ETS variant 3 like | module_4 | 25 | |
| ETV4 | ETS variant 4 | module_4 | 27 | |
| KAT2A | lysine acetyltransferase 2A | module_5 | 27 | |
| RARA | retinoic acid receptor alpha | module_5 | 27 | |
| BGLAP | bone gamma-carboxyglutamate protein | module_5 | 25 | |
| SP2 | Sp2 transcription factor | module_5 | 27 | |
| ANKRD11 | ankyrin repeat domain 11 | module_5 | 11 | |
| AKAP13 | A-kinase anchoring protein 13 | module_5 | 10 | |
| growth related modular genes not significantly enriched to any developmental process | GABRG1 | gamma-aminobutyric acid type A receptor gamma1 subunit | module_2 | 4 |
| NGF | nerve growth factor | module_2 | 26 | |
| APOBEC2 | apolipoprotein B mRNA editing enzyme catalytic subunit 2 | module_5 | 26 | |
| STAT5B | signal transducer and activator of transcription 5B | module_3 | 27 | |
| STAT3 | signal transducer and activator of transcription 3 | module_5 | 27 | |
| SMAD4 | SMAD family member 4 | module_5 | 25 | |
| MED1 | mediator complex subunit 1 | module_5 | 27 | |
| growth related modular genes reported in previous studies | CACNB1 | calcium voltage-gated channel auxiliary subunit beta 1 | module_2 | 27 |
| SLAIN2 | SLAIN motif family member 2 | module_5 | 4 | |
| LEMD2 | LEM domain containing 2 | module_5 | 26 | |
| ZC3H18 | zinc finger CCCH-type containing 18 | module_5 | 11 | |
| TMEM132D | transmembrane protein 132D | module_2 | 15 | |
| FRYL | FRY like transcription coactivator | module_4 | 4 | |
| SGCB | sarcoglycan beta | module_2 | 4 |