Fig. 3.

CDKN2A loss in ATC and advanced DTCs. a Detection of CDKN2A loss in ATC using WGS. b Detection of CDKN2A loss in ATC using targeted sequencing. c The frequency of CDKN2A loss among diverse types of TC were represented by a radar chart. d The distribution of TP53 and CDKN2A alterations across 113 advanced TCs. e The effect of CDKN2A loss on thyroid differentiation score (TDS) in ATC. P-values from two-tailed Mann–Whitney U-test were represented. f The effect of CDKN2A loss on disease-specific survival in patients with ATC and advanced DTCs. del and 2n indicate CDKN2A copy number loss and neutral, respectively. g The effect of p16 expression on disease-specific survival in patients with ATC and advanced DTCs. P-values from Log-rank test were represented