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. 2019 Jun 24;10:2764. doi: 10.1038/s41467-019-10680-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The potential druggable targets of ATC. a The top 15 significantly up-regulated KEGG pathways in BRAF^V600E-positive and RAS-positive ATCs. The significance of these pathways were also noted in PTC, FA/miFTC, and wiFTC, as they were also found within the top 15 significantly up-regulated pathways of each tumor. b The increment levels of genes in the JAK-STAT-signaling pathway in RAS-positive ATC compared with FA/miFTC/wiFTC were represented by Log₂(fold-change) values. Asterisks indicate the genes that were also up-regulated BRAF^V600E-positive ATC. c Quantitative reverse transcription polymerase chain reaction measurement of expression of JAK-STAT-signaling pathway genes and d cell viabilities analyzed by cell counting kit-8 assay, in CAL72 cells following treatment with ruxolitinib (1, 10, 20, and 25 μM). Ctrl denotes control. All data were expressed as mean ± standard deviation. *P < 0.05 from two-tailed Mann–Whitney U-test (compared with controls). e The expression levels of CD274 and PDCD1LG2 in various types of TC. f The relationship between the up-regulation of two immunotherapeutic genes and CDKN2A loss. Samples were sorted by high to low TDS