Table 1.
Clinicopathological characteristics of patients according to the histology
| ATC | PDTC | Focal ATC/PDTC | wiFTC | Metastatic PTC | |
|---|---|---|---|---|---|
| N | 27 | 15 | 28 | 12 | 31 |
| Fresh frozen tissue | 14 | 2 | 5 | 9 | 4 |
| FFPE tissue | 13 | 13 | 23 | 3 | 27 |
| Agea | |||||
| Initial diagnosis | 60.2 ± 15.3 | 55.3 ± 19.9 | 56.0 ± 15.9 | 65.3 ± 12.7 | 56.0 ± 9.7 |
| Surgeryb | 64.7 ± 12.4 | 55.8 ± 20.1 | 57.9 ± 16.5 | 65.4 ± 12.7 | 60.4 ± 8.2 |
| Male, n (%) | 10 (37.0) | 4 (26.7) | 8 (28.6) | 6 (50.0) | 9 (29.0) |
| Tumor origin | |||||
| PTC, n (%) | 16 (59.3) | 6 (40.0) | 27 (96.4) | 0 (0) | 31 (100) |
| FTC, n (%) | 8 (29.6) | 6 (40.0) | 1 (3.6) | 12 (100) | 0 (0) |
| Unknown, n (%) | 3 (11.1) | 3 (20.0) | 0 (0) | 0 (0) | 0 (0) |
| Distant metastasis, n (%) | 20 (74.1) | 6 (40.0) | 7 (25.0) | 10 (83.3) | 31 (100) |
| Final disease status | |||||
| NED, n (%) | 3 (11.1) | 11 (73.3) | 19 (67.9) | 3 (25) | 3 (9.7) |
| AWD, n (%) | 4 (14.8) | 2 (13.3) | 4 (14.3) | 8 (66.7) | 16 (51.6) |
| DOD, n (%) | 20 (74.1) | 2 (13.3) | 5 (17.9) | 1 (8.3) | 12 (38.7) |
| Disease-specific survival, monthsc | 6.9 (2.4–13.2) | 60.3 (36.9–121.0) | 109.2 (20.1–124.7) | 25.7 (13.6–73.7) | 44 (21.8–109.8) |
ATC anaplastic thyroid cancer, PDTC poorly differentiated thyroid cancer, wiFTC widely invasive follicular thyroid cancer, PTC papillary thyroid cancer, FTC follicular thyroid cancer, NED no evidence of disease, FFPE formalin-fixed paraffin-embedded, AWD alive with disease, DOD death of disease
aValues presented as mean ± standard deviation
bAge at surgery for analyzed tissue
cValues presented as median (interquartile range)