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. 2019 Jun 24;9:9099. doi: 10.1038/s41598-019-45284-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Topographical induced decrease in both nucleus and total cell size. (A) Dynamic change of nucleus volume (N > 11) in hMSCs cultured on flat and topography M after 1, 3, 8, 24, and 96 hours as quantified using confocal micrographs. (B) Volume views of representative nuclei after 1 and 8 hours on flat, and after 96 hours on flat and topography M. (C) Confocal micrograph quantification of nucleus volumes of cells on topographies with varying topographical feature size (S, M, and L) after 72 hours (N = 4). (D) Flow cytometer measurements of relative cell size after 72 hours on topographies with varying topographical feature size (S, M, and L) (N = 4). Statistical significance stars represent differences between conditions at a given time point with p < 0.05.