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. 2019 Jun 24;9:9099. doi: 10.1038/s41598-019-45284-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surface topography adapted hMSCs are more resistant to anti-cancer drugs. (A) dose-response curve of MSC survival after a 44 hours paclitaxel treatment (N = 3). The difference between cell numbers for cells exposed to paclitaxel cultured on Flat and Topo M were found to be significantly different with p < 0.05. (B) Differential resistance to paclitaxel of MSC cultured on flat of topographically enhanced substrates after 44 hours. Cell counts are normalized to the basic medium condition. (C) Representative micrographs of nuclei staining after 44 hours of exposure to 300 µM paclitaxel on flat (left) and topography M (right). Scale bar represents 50 µm.