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. 2019 Jun 18;10:1322. doi: 10.3389/fimmu.2019.01322

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Copyright © 2019 Valentine and Hoyer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCR5+ CD8 T cell function is anatomically instructed. (A) Antigen-specific CXCR5+ CD8 T cells in peripheral blood circulation induce direct cell killing, whereas other CD8 T cells may be functionally exhausted. (B) CXCR5+ CD8 T cells within secondary lymphoid organs that localize to the extrafollicular space maintain higher direct cell killing capacity than CXCR5+ CD8 T cells within the follicle. Antigen-specific CXCR5+ CD8 T cells are maintained at similar frequency in the extrafollicular space and follicle. (C) Follicular CXCR5+ CD8 T cells maintain the capacity for cytotoxicity; different antigen scenarios likely elicit various functional outcomes that promote direct B cell or CD4 Tfh cell interactions. Dark blue cells indicate antigen specific T cells. Dashed lines indicate potential interactions.