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. 2019 Jun 18;13:615. doi: 10.3389/fnins.2019.00615

FIGURE 3.

FIGURE 3

Analyses of average basal and intrinsic (dual autonomic blockade) HR and selected HRV parameters of in vivo EKG time series. (A) Average RR interval length. (B) Range of RR intervals, interaction F-value of 30.223, p-value of 0.0002. (C) Standard deviation of RR intervals, interaction F-value of 20.541, p-value of 0.001. (D) Total power. (E) Very low frequency power. (F) Low frequency power, interaction F-value of 14.415, p-value of 0.003. (G) High frequency power, interaction F-value of 5.184, p-value of 0.046. (H) Poincare plot SD1, interaction F-value of 24.921, p-value of 0.0005. (I) Poincare plot SD2, interaction F-value of 17.884, p-value of 0.001. (J) Multiscale entropy, interaction F-value of 119.116, p-value of 7.09E-07. Tp < 0.05 for main effects of drug differences. *p < 0.05 for significant pairwise differences, if a significant interaction effect was found, as determined by a linear mixed effects model. F-value and p-value provided for significant interactions. N = 6 for WT and N = 6 for TGAC8.