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. 2019 Jun 18;10:764. doi: 10.3389/fphys.2019.00764

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Copyright © 2019 Brothers, Zhuo, Papah and Abasht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation network diagrams for PPARA (left) and palmitic acid (right). Pink and green shapes represent genes upregulated or downregulated in males, respectively. Orange arrows represent IPA’s prediction that the upstream regulator activates the corresponding genes. Yellow arrows represent disagreement between the direction of the gene expression (i.e., up or downregulation) and IPA’s prediction of the relationship between the upstream regulator and the corresponding gene. Gray arrows mean that IPA predicts a relationship between the upstream regulator and the corresponding gene but cannot predict the exact effect. Image produced using IPA.