TABLE 3.

Relationship between age and cortical thickness according to the diagnostic groups.

	Global			Frontal			Temporal			Parietal			Occipital
	B	SE	P	B	SE	P	B	SE	P	B	SE	P	B	SE	P
CN
Age	–0.004	$<0.001$	$<0.001$	–0.004	$<0.001$	$<0.001$	–0.004	$<0.001$	$<0.001$	–0.005	$<0.001$	$<0.001$	–0.005	$<0.001$	$<0.001$
SMI
Age	–0.006	$<0.001$	$<0.001$	–0.006	$<0.001$	$<0.001$	–0.007	0.001	$<0.001$	–0.005	$<0.001$	$<0.001$	–0.006	$<0.001$	$<0.001$
Early-stage aMCI
Age	–0.009	0.001	$<0.001$	–0.009	0.001	$<0.001$	–0.012	0.001	$<0.001$	–0.009	0.001	$<0.001$	–0.008	0.001	$<0.001$
Late-stage aMCI
Age	–0.008	0.001	$<0.001$	–0.008	0.001	$<0.001$	–0.010	0.001	$<0.001$	–0.007	0.001	$<0.001$	–0.006	0.001	$<0.001$
Very mild AD
Age	–0.005	0.001	$<0.001$	–0.006	0.001	$<0.001$	–0.007	0.001	$<0.001$	–0.002	0.001	0.079	–0.002	0.001	0.061
Mild AD
Age	–0.001	0.001	0.416	–0.002	0.001	0.009	–0.003	0.001	0.012	0.003	0.001	0.001	0.002	0.001	0.095
Moderate to severe AD
Age	0.002	0.001	0.179	0.001	0.001	0.436	$<0.001$	0.002	0.827	0.006	0.001	$<0.001$	0.002	0.002	0.193

B (SE): β value (standard error of the mean). Multiple linear regression analysis was performed after controlling for sex, education years (continuous), ICV, vascular risk factors (hypertension, diabetes mellitus, and hyperlipidemia), and history of ischemic heart disease or stroke. CN, cognitively normal; SMI, subjective memory impairment; aMCI, amnestic mild cognitive impairment; AD, Alzheimer’s disease.