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. 2019 Jun 24;10:2760. doi: 10.1038/s41467-019-10591-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Cardiac effects of PPP1R3A ablation in vivo. a Fractional shortening is preserved in Ppp1r3a^−/− mice after TAC. At 6 weeks (n = 5 animals for all groups), Ppp1r3a^−/− TAC 37.6 ± 4.3%, Ppp1r3a^−/− Sham 36.5 ± 4.7%, Ppp1r3a^+/+ TAC 26.7 ± 9.5%, Ppp1r3a^+/+ Sham 41.2 ± 8.4%, p = 0.03 ANOVA and p = 0.03 for Ppp1r3a^−/− TAC vs. Sham by Bonferroni post test. At 8 weeks (n = 5 for all groups), Ppp1r3a^−/− TAC 37.9 ± 2.8%, Ppp1r3a^−/− Sham 41.6 ± 6.8%, Ppp1r3a^+/+ TAC 24.4 ± 9.0%, Ppp1r3a^+/+ Sham 38.5 ± 2.8%, p = 0.002 (ANOVA) and p = 0.01 for Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). b Gene expression of HF markers is not increased in Ppp1r3a^−/− animals after TAC: PPP1R3a: p < 0.0001 (ANOVA), p < 0.0001 Ppp1r3a^+/+ vs Ppp1r3a^−/− TAC and Ppp1r3a^+/+ vs. Ppp1r3a^−/− Sham, but p = 0.41 Ppp1r3a^+/+ TAC vs. Sham (Bonferroni post test). MYH7/MYH6: p = 0.11 (ANOVA), p = 0.45 Ppp1r3a^+/+ TAC vs. Sham and p = 1.0 Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). Nppa: Ppp1r3a^+/+ Sham 1 ± 0.18 (mean fold change ± SD), Ppp1r3a^+/+ TAC: 4.8 ± 2.6, Ppp1r3a^−/− Sham: 1.5 ± 1.1, Ppp1r3a^−/− TAC: 2.5 ± 1.1. p = 0.006 (ANOVA), p = 0.006 Ppp1r3a^+/+ TAC vs. Sham and p = 1.0 Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). Nppb: Ppp1r3a^+/+ Sham 1 ± 0.11, Ppp1r3a^+/+ TAC: 4.1 ± 1.9, Ppp1r3a^−/− Sham: 1.4 ± 1.1, Ppp1r3a^−/− TAC: 2.6 ± 1.5. p = 0.008 (ANOVA), p = 0.01 Ppp1r3a^+/+ TAC vs. Sham and p = 1.0 Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). c Preservation of cardiomyocyte size in Ppp1r3a^−/− animals after TAC: p = 0.004 (ANOVA), p = 0.004 Ppp1r3a^+/+ TAC vs. Sham and p = 0.64 Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). Scale bar indicates 20 μm length. d Fibrosis is not increased in Ppp1r3a^−/− animals after TAC (p < 0.0001 (ANOVA), p = 0.001 Ppp1r3a^+/+ TAC vs. Sham and p = 0.22 Ppp1r3a^−/− TAC vs. Sham (Bonferroni post test). Scale bar indicates 200 μm length. *p ≤ 0.05 (Bonferroni post test), TAC transaortic constriction. Error bars indicate standard error of the mean. Source data for this figure are provided in a source data file