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. 2019 Jun 24;9:9138. doi: 10.1038/s41598-019-45681-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MPTP-induced degeneration of dopaminergic neurons is enhanced in Cav1.2KD mice. (a) Brain slices containing the SNc area from wild type (WT) and Cav1.2KD mice treated with MPTP were immunostained with a TH-antibody to detect dopaminergic neurons. (b) Number of dopaminergic neurons in the SNc 7 days after MPTP administration, normalized with normal controls (saline treated), was compared between WT and Cav1.2KD. (c) Images of the mouse brain CPu area immunostained with a TH-antibody to show the terminals of the SNc dopaminergic neurons. The boxed area in the inset image represents the CPu area shown in (c). (d) Analysis of the TH-ir signal intensity in the CPu. Scale bars, 200 µm. The numbers in the columns in (b,d) represent the number of mice analysed. Data are presented as mean ± SEM. *p < 0.05 by a Student’s t-test.