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. 2019 Jun 24;9:9138. doi: 10.1038/s41598-019-45681-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knocking down of microglial Cav1.2 exacerbated the reduction in the spontaneous activity and deficits in motor functions in the MPTP model of PD. (a–c) Analyses of the ratio (post-MPTP/pre-MPTP) of the number of rears (a), forelimb steps (b), and hindlimb steps (c) in the cylinder test. (d–g) Results of the challenging beam traversal test performed after MPTP administration. (d) Number of errors in the total length. (e) Errors per step in the total length (1 m) of the beam. (f) Error numbers in each width of the beam (3.5 cm, 2.5 cm, 1.5 cm, and 0.5 cm). (g) Errors per step in each width. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 by Welch’s t-test (a,c) or by a Student’s t-test (d,e) or a Tukey-Kramer test (f,g). The numbers shown in the columns in all the panels represent the number of mice analysed.