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. 2019 Jun 24;9:9111. doi: 10.1038/s41598-019-45585-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of PRMT1 activity shift in alcohol fed mice. There are two forms of PRMT1, the S297 phosphorylated form that predominates in the non-alcohol condition and a de-phosphorylated form that is generated after alcohol exposure. The phosphorylated form is more efficient in promoting the expression of cytokines, HNF4α and MMP7, BIM and TRAIL expression. Phosphorylation independent functions include Cpt1 expression, ADMA generation and the antioxidant stress response.