TABLE 4.

Relationship of sex hormones to gray matter volumes in the hippocampus and middle frontal gyrus (MFG) while controlling for biological sex.

	HippocampusL		HippocampusR		MFG_L		MFG_R
	b	t	b	t	b	t	b	T
Sex	0.10	0.97	0.02	0.21	0.24	1.99∗	0.30	2.55∗∗
Age	–0.02	–0.33	–0.05	–0.73	–0.19	–2.54∗	-0.21	–2.81∗∗
TIV	0.55	6.56∗∗∗	0.64	7.69∗∗∗	0.39	3.92∗∗∗	0.51	5.23∗∗∗
Estradiol	–0.11	–1.56	–0.10	–1.43	–0.03	–0.34	–0.07	–0.88
Progesterone	–0.01	–0.15	0.10	1.07	–0.03	–0.22	0.16	1.44
Testosterone	0.37	2.88∗∗	0.12	0.92	0.16	1.07	–0.18	–1.19
Sex × Estradiol	–0.01	–0.09	0.03	0.37	–0.02	–0.26	0.06	–0.72
Sex × Prog	0.05	0.58	–0.06	–0.66	–0.13	–1.19	–0.14	–1.35
Sex × Test	0.26	2.44∗	0.22	2.05∗	0.19	1.50	–0.10	–0.83

MFG = middle frontal gyrus. L, left; R, right. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001. Significant effects are highlighted in bold font.