Table 1.
Potential anxiolytic and antidepressant effects of B. adolescentis.
| B. Immobility Duration of Forced swimming test (%) | C. Total Distance of Open Field (cm) | D. Time in Center of Open Field (%) | E. Total Entries of EPM | F. Entries in Open Arms of EPM (%) | G. Time in Open Arms of EPM (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Con | Ami (10 mg/kg) | Bif (0.25×109 CFU/kg) | Bif (0.5×109 CFU/kg) | Bif (1×109 CFU/kg) | Con | Bif (0.25×109 CFU/kg) | Con | Bif (0.25×109 CFU/kg) | Con | Bif (0.25×109 CFU/kg) | Con | Bif (0.25×109 CFU/kg) | Con | Bif (0.25×109 CFU/kg) |
| 39.17 | 2.5 | 28.89 | 22.22 | 16.69 | 1263.21 | 2053.69 | 4.43 | 7.34 | 15 | 10 | 26.67 | 20.00 | 32.24 | 26.28 |
| 27.78 | 4.44 | 23.17 | 12.5 | 14.81 | 1595.11 | 2465.83 | 4.67 | 12.69 | 14 | 8 | 14.29 | 37.50 | 14.92 | 35.56 |
| 21.94 | 23.06 | 11.11 | 29.72 | 17.08 | 1121.71 | 1635.51 | 2.51 | 9.32 | 16 | 26 | 12.50 | 34.62 | 18.52 | 62.16 |
| 21.39 | 3.06 | 22.08 | 7.22 | 13.97 | 1242.33 | 2493.29 | 2.44 | 12.36 | 8 | 18 | 12.50 | 16.67 | 33.28 | 34.88 |
| 30.56 | 10.56 | 6.39 | 25 | 12.67 | 1382.98 | 504.9 | 5.37 | 8.56 | 19 | 12 | 0.00 | 41.67 | 0 | 54.24 |
| 23.06 | 31.11 | 25.83 | 13.06 | 30.67 | 1480.85 | 971.53 | 9.64 | 4.28 | 18 | 15 | 11.11 | 40.00 | 10.24 | 31.48 |
| 24.44 | 14.17 | 12.78 | 23.33 | 15.47 | 1577.51 | 1446.7 | 0.45 | 6.13 | 7 | 22 | 14.29 | 18.18 | 26.4 | 42.32 |
| 51.11 | 18.06 | 20.28 | 15.83 | 20.27 | 972.73 | 2119.14 | 3.35 | 4.21 | 9 | 27 | 33.33 | 25.93 | 42.52 | 32.76 |
| 23.06 | 35 | 18.06 | 18.61 | 26.53 | 2412.68 | 1785.53 | 6.4 | 14.25 | 22 | 15 | 13.64 | 20.00 | 14.72 | 28 |
| 27.22 | 21.11 | 19.72 | 20 | 22.42 | 1324.97 | 1272.91 | 4.65 | 7.2 | 12 | 15 | 25.00 | 26.67 | 48.6 | 20.52 |
| compared with control t-test for Equality of Means | compared with control | compared with control | compared with control | compared with control | compared with control | |||||||||
| t-test for Equality of Means | t-test for Equality of Means | t-test for Equality of Means | t-test for Equality of Means | t-test for Equality of Means | ||||||||||
| p = 0.015 | 0.013 | 0.012 | 0.011 | p = 0.333 | p = 0.006 | 0.292 | 0.013 | 0.059 | ||||||
| df = 18 | 18 | 18 | 18 | df = 18 | df = 18 | df = 18 | df = 18 | df = 18 | ||||||
| t = 2.698 | 2.741 | 2.794 | 2.824 | t = −0.995 | t = −3.11 | t = −1.087 | t = −2.768 | t = −2.018 | ||||||
The mice in groups of Con, Ami (10 mg/kg), Bif(0.25×109 CFU/kg), Bif (0.5×109 CFU/kg) and Bif (1×109 CFU/kg) were given with distilled water (10 mL/kg), amitriptyline (10 mg/kg), B. adolescentis (0.25×109 CFU/kg), B. adolescentis (0.5×109 CFU/kg) and B. adolescentis (1×109 CFU/kg) respectively, by gavage for 21 days. N = 10 per group.