Table 2.
Anxiolytic and antidepressant effects of B. adolescentis in CRS mice.
B. Time in Center of Open Field (%) | C. Total Distance of Open Field (cm) | D. Total Entries of EPM | E. Entries in Open Arms of EPM (%) | F. Time in Open Arms of EPM (%) | G. Immobility Duration of Tail Suspension Test (%) | H. Immobility Duration of Forced swimming test (%) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Con | CRS | Bif+CRS | Con | CRS | Bif+CRS | Con | CRS | Bif+CRS | Con | CRS | Bif+CRS | Con | CRS | Bif+CRS | Con | CRS | Bif+CRS | Con | CRS | Bif+CRS |
5.39 | 0.32 | 2.6 | 1941.64 | 1658.32 | 1543.94 | 15 | 13 | 8 | 20.00 | 15.38 | 25.00 | 21.32 | 16.32 | 23.17 | 22.05 | 34.53 | 11.55 | 5.9 | 19.33 | 15.18 |
5.81 | 2.84 | 12.29 | 1977.99 | 1462.89 | 2161.88 | 19 | 21 | 14 | 26.32 | 14.29 | 28.57 | 25.44 | 24.48 | 36.54 | 2.82 | 42.82 | 12.15 | 8.31 | 15.45 | 2.22 |
8.02 | 3.78 | 1.7 | 2243.67 | 1696.25 | 2026.44 | 23 | 5 | 6 | 21.74 | 0.00 | 16.67 | 23.58 | 0 | 17.25 | 1.35 | 24.54 | 32.22 | 22 | 29.35 | 14.88 |
6.96 | 0.56 | 6.97 | 1854.72 | 1604.73 | 2330.81 | 10 | 8 | 20 | 20.00 | 12.50 | 20.00 | 21.95 | 15.12 | 18.94 | 14.9 | 22.68 | 17.27 | 6.83 | 35.9 | 1.03 |
7.01 | 3.02 | 5.51 | 1936.98 | 2234.28 | 2407.91 | 25 | 24 | 10 | 16.00 | 16.67 | 20.00 | 28.33 | 18.29 | 23.19 | 5.25 | 22.4 | 0 | 9.88 | 10.32 | 7.53 |
4.51 | 3.76 | 10.56 | 2572.29 | 1902.54 | 1907.05 | 6 | 15 | 9 | 16.67 | 6.67 | 33.33 | 22.03 | 10.54 | 34 | 24.03 | 14.9 | 12.77 | 9.62 | 22.03 | 3.63 |
2.46 | 1.46 | 4.62 | 1704.71 | 1608.22 | 2393.15 | 21 | 10 | 30 | 28.57 | 20.00 | 23.33 | 34.26 | 29.98 | 20.05 | 11.58 | 13.92 | 13.02 | 19.22 | 7.22 | 24.97 |
3.71 | 4.98 | 6.31 | 1965.25 | 1994.96 | 1623.36 | 8 | 22 | 22 | 12.50 | 13.64 | 9.09 | 9.35 | 14.76 | 5.27 | 13.52 | 11.15 | 6.68 | 0.62 | 18.73 | 7.67 |
16.11 | 3.96 | 2.26 | 2274.03 | 1956.94 | 2101.34 | 17 | 11 | 19 | 17.65 | 9.09 | 15.79 | 29.42 | 10 | 15.74 | 0.4 | 33.27 | 19.03 | 1.05 | 7.52 | 5.53 |
4.64 | 3.96 | 12.06 | 1529.13 | 1588.10 | 2308.45 | 10 | 18 | 27 | 10.00 | 11.11 | 18.52 | 4.54 | 11.85 | 19.57 | 5 | 21.32 | 18.25 | 7.03 | 15.78 | 1.7 |
5.6 | 6.53 | 13.08 | 2111.62 | 2502.09 | 2453.90 | 20 | 12 | 17 | 25.00 | 8.33 | 23.53 | 26 | 7.42 | 22.46 | 35.6 | 13.92 | 3.95 | 12.27 | 18.25 | 21.28 |
10.18 | 3.51 | 2.25 | 2385.22 | 1873.10 | 1532.85 | 18 | 19 | 8 | 16.67 | 15.79 | 25.00 | 17.55 | 14.11 | 26.57 | 23.95 | 12.72 | 9.65 | 8.64 | 20.33 | 3.08 |
df | F | P | df | F | P | df | F | P | df | F | P | df | F | P | df | F | P | df | F | P |
2,33 | 4.183 | 0.024 | 2,33 | 1.875 | 0.169 | 2,33 | 0.104 | 0.901 | 2,33 | 9.108 | 0.001 | 2,33 | 3.465 | 0.043 | 2,33 | 3.422 | 0.045 | 2,33 | 5.78 | 0.007 |
The mice in groups of Con, CRS and Bif+CRS were given with distilled water (10 mL/kg), distilled water (10 mL/kg), B. adolescentis (0.25×109 CFU/kg) respectively, by gavage for 21 days. N = 12 per group.