Table 5.
Changes in the protein expression of BDNF, IL-1β, TNF-α, p-NF-κB p65 and Iba1 in the hippocampus induced by pretreatment with B. adolescentis.
| B. Western blotting analysis for BDNF, IL-1β, TNF-α, p-NF-κ B p65 and Iba1 expression | |||||
|---|---|---|---|---|---|
| BDNF | IL-1β | TNF-α | p-NF-κB p65/NF-κB p65 | Iba1 | |
| Con | 1.0723 | 0.9218 | 0.9743 | 0.9441 | 1.1421 |
| 1.0099 | 1.1345 | 0.8306 | 0.8215 | 0.7453 | |
| 1.0872 | 0.8812 | 1.0628 | 1.1499 | 1.1128 | |
| 0.8307 | 1.0634 | 1.1325 | 1.0852 | 1.0011 | |
| CRS | 0.4894 | 1.1463 | 1.9127 | 1.1227 | 1.1859 |
| 0.6007 | 1.3988 | 1.7253 | 1.2378 | 1.1808 | |
| 0.6971 | 1.3309 | 1.3475 | 1.4009 | 1.3169 | |
| 0.5803 | 1.3691 | 1.5323 | 1.4565 | 1.5296 | |
| Bif+CRS | 1.5287 | 0.6976 | 1.1223 | 0.9601 | 0.8247 |
| 1.1179 | 0.9694 | 1.3875 | 0.8072 | 1.0179 | |
| 1.1195 | 1.0616 | 1.1956 | 0.9221 | 0.9956 | |
| 0.6419 | 0.9869 | 1.1328 | 1.0082 | 0.8336 | |
| df | 2,9 | 2,9 | 2,9 | 2,9 | 2,9 |
| F | 5.731 | 9.477 | 13.469 | 9.3 | 7.066 |
| P | 0.025 | 0.006 | 0.002 | 0.006 | 0.014 |
The mice in groups of Con, CRS and Bif+CRS were given with distilled water (10 mL/kg), distilled water (10 mL/kg), B. adolescentis (0.25×109 CFU/kg) respectively, by gavage for 21 days. N = 4 per group.