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. 2019 Jun 18;13:613. doi: 10.3389/fnins.2019.00613

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Copyright © 2019 Kim, Schmidt, Deemie, Wycech, Liang and Giszter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Various possible BMEP designs. (A) Variable recording/stimulation sites at tips and on the body over a sharp tip rod or micropipette. Black dots represent the recording or stimulation sites. (B) Variable recording/stimulation sites with a protective arrow head to protect tips of braid during insertion and provide easier penetration. (C) Example of using biodegradable filaments to wrap wire bundles which are the microelectrodes. After insertion into neural tissue, the straight wire bundle unwrap gradually because the wrapping filaments are degraded in the tissue. (D) Example of using biodegradable filaments (white) with microwires (hatched) braided together. Only the microwires in a loose helical form are left in the tissue after biodegradation of the other (white) filaments which are completely dissolved. These drawings are from our US patent (Giszter, 2016).