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. 2019 Jun 18;13:613. doi: 10.3389/fnins.2019.00613

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Copyright © 2019 Kim, Schmidt, Deemie, Wycech, Liang and Giszter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulation results. (A) Left hand side of the figure shows simulated site activity without noise added in blue, and independent components derived from noisy wire outputs in red. The four different spike shapes can be detected in this figure. On the right hand side of the figure, a site level collision is observed, and preserved by ICA. The activation scale and signal scale differ but the correlation coefficient of the reconstruction is 0.99. (B) DBSCAN method showing recovery of only clean non-colliding spikes. (C) Plexon Offline Sorter (POS) extracted spikes showing variation in spikes shapes caused by presence of spike collisions that are being assigned to spike clusters.