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. 2019 Jun 24;9:9139. doi: 10.1038/s41598-019-45579-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic value of the 4-GES in 162 cytogenetically normal AML patients (GSE12417, cohort 1). (A) Cut-off value for stratification of AML patients into 4-GES^low (blue) and 4-GES^high (red) was calculated by maximally selected rank statistics. (B) Kaplan Meier curves for overall survival of 162 AML patients classified as 4-GES^low or 4-GES^high. Log rank tests were calculated and p-values were adjusted for multiple testing according to Altman et al.⁵⁸. (C) Heatmap summarizing expression values of SOCS2, IL2RA, NPDC1 and PHGDH in 4-GES^low (blue) and 4-GES^high (red) AML patients. Blue, low expression; red, high expression.